TLDR: Cells become islands of raised K+ ion concentration when energy is supplied. Okay, here come the doodles based on Skulachev's paper. Membrane- linked energy buffering as the biological function of Na+/K+ gradient. This is the scenario in ultra modern bacteria, the pinnacle of about 4 billion years of evolution. The membrane is tight to all significant ions at reasonable temperatures and concentration gradients. Bulking For Endomorphs Gaining Muscle While Limiting Fat Gains. Chapter 1 - Introduction Chapter 2 - What Makes An Endomorph An Endomorph Chapter 3 - Glucose Uptake. As The Eating Academy approaches its first birthday in about a month, I figured it was as good a time as any to put together some thoughts on a subject I get asked. A healthy omentum is a thin, pale yellow sheet that contains fat and often has a lacy appearance. Fat is an essential substance in our body. It only becomes dangerous. In this set of pictures the proton population represented within the red circle is holding a membrane voltage of 1. V, as per usual: The trans- membrane potential from the pumped protons is stable while ever the pumping and the consumption of protons is balanced. The problem is that it doesn't need many protons to generate that 1. V. Pumping any more than basic needs generates too great a membrane voltage. The converse is that it doesn't take much excess proton consumption to collapse the potential. So you need a buffer which does not waste the energy used to pump. If a bacterium suddenly increases proton pumping by eating some glucose we have this problem of a spike in membrane voltage: We can get around this by allowing a positive ion to travel in the opposite direction. This will stop the rising membrane potential as the ion uses the membrane potential to enter the cell against a concentration gradient. French translation. When was the last time you saw an obese lion? How about a chubby cheetah? Or a fat tiger? Have you ever seen an overweight leopard or panther? Top of page Introduction. Obesity is defined as a condition in which excessive fat accumulates in the body, which can result in many health-related problems. It uses an ion- specific channel, in this case for potassium. This process is electrophoresis down the electrical gradient, against a concentration gradient, powered by the electrical component rather than the p. H component of the rising proton gradient: The number of K+ ions matches the excess protons pumped. The electrical potential is thus maintained at 1. V at the . But there is a problem in that the more protons pumped and the more K+ entering the cell, the higher the p. H of the intracellular medium becomes. That K+ pool is actually tied to the OH- left behind by pumping out H+. Caustic potash.. This is not good for metabolic processes. But it is easily surmounted using a 1: 1 ratio Na+/H+ (electro- neutral) antiporter to get some protons back in to the cell to offset the excess OH- while still maintaining an electrical gradient of 1. V using H+, keeping an electro- neutral Na+/K+ gradient as an energy store: Obviously the Na+/H+ antiporter is being driven by the p. H component of the proton gradient. It's neat how evolution has separated out the p. H and electrical components of a proton gradient! The whole system is fully reversible so if there is a sudden drop in proton pumping the transmembrane Na+/K+ gradient can be reconverted to a proton gradient to . This seems to be how modern, proton pumping bacteria with superbly proton tight membranes work. In E coli the ion channel and antiporter are ATP gated. That's how Skulachev looked at modern bacteria in 1. I'm now going to wander off on my own and speculate about LUCA with a proton leaky but Na+/K+ tight membrane. This is just me from here onwards: Let's have a think about LUCA, with a cell membrane which is tight to Na+, and probably K+ too, but highly leaky to both protons and hydroxyl ions. Metabolism is based on Na+ pumping and a Na+ specific ATP synthase. The initial Na+/H+ antiporter (from the Life series) is gone as a source of Na+ gradient as soon as LUCA leaves the alkaline hydrothermal vents. I like the idea that LUCA used a pyrophosphatase to pump Na+ but with any Na+ pump we have the same problem as in modern bacteria: You can only store a small amount of energy as a 1. V Na+ gradient, as per H+ above: But excess Na+ pumping can be easily be accommodated by K+ electrophoresis: There is no need for the Na+/H+ antiporter in this scenario because there is no p. H change associated with pumping Na+ ions, so all we need is the ion specific channel for K+. This sets up a non- electrical energy store which is . We have here, based on a tiny step beyond Skulachev's ideas, a place within LUCA which is potassium rich. It's simply produced to buffer changes in ion pumping by the primary Na+ pump (or usage by ATP synthase) across relatively primitive membranes. And driving intracellular K+ higher is an indicator to the cell that there is excess of energy available, which should select for increased enzyme activity based on rising intracellular K+ concentration. Many of the . Remember that for our later discussion about Mulkidjanian's ideas on the origin of life on Earth. ALL NATURAL FAT BURNERS FOR MAXIMUM ENERGY & EFFECTIVENESS. Prescription diet drugs may be good for some people, but a growing number of dieters are looking for a.
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